The second most populous city in Minnesota, Saint Paul sits aside the majestic Mississippi River. Sports fans will be in heaven in Saint Paul, with access to Minnesota Twins and Vikings games. The city is packed with recreational options, such as parks and zoos, boutiques, galleries and eateries. The Frederick R. Weisman Art Museum is a must-see. Housed in a building designed by Frank Gehry, the museum's collection is extensive and sharply curated. Foodies will find themselves right at home, with a bevy of artisanal and local products available at farmers markets and grocers. Beer fans will delight in local craft brewing options, such as world-class breweries like Summit and Surly.